Complexity
Nervous system is more structurally complex whereas endocrine system is less structurally complex.
Structure
Nervous system involves systems of neurones which branch throughout body whereas endocrine system involves endocrine glands which secrete hormones into the bloodstream and are carried to target organs.
Communication
In nervous system, neurones conduct electrical signals directly to and from specific targets whereas in endocrine system, hormones circulate throughout whole body in bloodstream.
Response time
In nervous system, transmission of nerve impulses is fast whereas in endocrine system, it may takes minutes, hours or days for hormones to be produced, carried in bloodstream to target organs and for responses to occur.